Edward H Schuchman Selected Research

Lipids

1/2023	Apolipoprotein-mimetic nanodiscs reduce lipid accumulation and improve liver function in acid sphingomyelinase deficiency.
1/2021	Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes.
11/2018	CD40 Enhances Sphingolipids in Orbital Fibroblasts: Potential Role of Sphingosine-1-Phosphate in Inflammatory T-Cell Migration in Graves' Orbitopathy.
1/2017	Types A and B Niemann-Pick disease.
1/2016	Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs administered new generation lipid emulsions.
2/2014	Inhibition of GM3 synthase attenuates neuropathology of Niemann-Pick disease Type C. by affecting sphingolipid metabolism.
1/2014	Pharmacological reversion of sphingomyelin-induced dendritic spine anomalies in a Niemann Pick disease type A mouse model.
1/2013	Use of acid sphingomyelinase for cancer therapy.
9/2011	Secondary alterations of sphingolipid metabolism in lysosomal storage diseases.
9/2009	Ceramide mediates inhibition of the AKT/eNOS signaling pathway by palmitate in human vascular endothelial cells.

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Edward H Schuchman Research Topics

Disease

44	Niemann-Pick Diseases (Niemann Pick Disease) 06/2023 - 05/2002
15	Inflammation (Inflammations) 06/2023 - 01/2006
14	Neoplasms (Cancer) 01/2019 - 05/2005
12	Farber Lipogranulomatosis 11/2023 - 02/2002
10	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 12/2006
10	Mucopolysaccharidoses 12/2019 - 05/2005
9	Lysosomal Storage Diseases (Lysosomal Storage Disease) 01/2021 - 12/2002
8	Type B Niemann-Pick Disease 01/2017 - 12/2002
7	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2023 - 05/2007
6	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 01/2023 - 05/2007
6	Type A Niemann-Pick Disease 01/2019 - 04/2009
5	Infections 10/2020 - 09/2014
5	Inborn Genetic Diseases (Disease, Hereditary) 10/2020 - 05/2007
4	Fibrosis (Cirrhosis) 10/2021 - 01/2010
4	Cystic Fibrosis (Mucoviscidosis) 10/2020 - 09/2014
4	Lung Diseases (Lung Disease) 10/2020 - 01/2010
3	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 11/2023 - 01/2016
3	Neuroinflammatory Diseases 01/2022 - 04/2009
3	Insulin Resistance 01/2021 - 09/2009
3	Pneumonia (Pneumonitis) 01/2019 - 03/2003
3	Atherosclerosis 09/2016 - 10/2008
3	Memory Disorders (Memory Loss) 01/2014 - 02/2010
2	Myoclonic Epilepsies (Myoclonic Encephalopathy) 11/2023 - 01/2016
2	Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy) 12/2022 - 10/2016
2	Reperfusion Injury 01/2021 - 01/2018
2	Necrosis 01/2021 - 01/2013
2	Neurologic Manifestations (Neurological Manifestations) 12/2019 - 01/2018
2	Gliosis 01/2019 - 10/2007
2	Gaucher Disease (Gaucher's Disease) 01/2017 - 02/2004
2	Mucopolysaccharidosis I (Hurler Syndrome) 01/2016 - 07/2007
2	Mucopolysaccharidosis VI (Syndrome, Maroteaux-Lamy) 01/2014 - 01/2011
2	Congenital Abnormalities (Deformity) 01/2013 - 01/2011
2	Joint Diseases (Joint Disease) 01/2010 - 01/2008
1	Fatty Liver 06/2023
1	Poisoning 10/2021
1	Silicosis 10/2021
1	Overnutrition 01/2021
1	Obesity 01/2021
1	Mucopolysaccharidosis II (Hunter Syndrome) 12/2019
1	Brain Diseases (Brain Disorder) 01/2019
1	Mucopolysaccharidosis III (Sanfilippo Syndrome) 01/2019
1	Graves Ophthalmopathy 11/2018
1	Graves Disease (Basedow Disease) 11/2018
1	Ischemia 01/2018
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2018
1	Ulcerative Colitis 01/2018
1	Bacterial Infections (Bacterial Infection) 06/2017

Drug/Important Bio-Agent (IBA)

47	AcidsIBA 06/2023 - 05/2002
45	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 06/2023 - 05/2002
31	neodymium pyrocatechin disulfonate (NPD)IBA 01/2019 - 05/2002
22	CeramidesIBA 11/2023 - 05/2005
21	EnzymesIBA 01/2023 - 07/2002
19	SphingolipidsIBA 11/2023 - 04/2009
19	LipidsIBA 01/2023 - 07/2002
16	SphingomyelinsIBA 01/2023 - 07/2002
11	Acid CeramidaseIBA 01/2021 - 02/2002
8	SphingosineIBA 12/2020 - 08/2003
6	Proteins (Proteins, Gene)FDA Link 11/2017 - 12/2002
5	Pentosan Sulfuric Polyester (Pentosan Polysulfate)FDA Link 12/2019 - 01/2013
4	CytokinesIBA 01/2019 - 05/2005
4	Amyloid (Amyloid Fibrils)IBA 01/2018 - 02/2010
4	GlycosaminoglycansIBA 01/2016 - 05/2005
3	CholesterolIBA 01/2023 - 09/2002
3	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 11/2018 - 01/2013
3	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/2017 - 01/2006
3	HydrolasesIBA 01/2013 - 09/2005
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2013 - 01/2010
3	Insulin (Novolin)FDA Link 09/2009 - 04/2003
3	Mannose (D-Mannose)IBA 08/2005 - 01/2004
2	ApolipoproteinsIBA 01/2023 - 10/2008
2	Amyloid beta-PeptidesIBA 01/2022 - 02/2010
2	EndocannabinoidsIBA 01/2021 - 11/2020
2	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 07/2004
2	Lysergic Acid Diethylamide (LSD)IBA 10/2020 - 10/2012
2	Oxygen (Dioxygen)IBA 01/2018 - 08/2013
2	AntibodiesIBA 06/2017 - 05/2013
2	Phenobarbital (Luminal)FDA Link 06/2017 - 09/2014
2	CeramidasesIBA 10/2016 - 02/2002
2	plerixafor FDA Link 11/2013 - 07/2011
2	Toll-Like Receptor 4IBA 01/2011 - 01/2010
2	Therapeutic UsesIBA 02/2010 - 01/2010
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 08/2007 - 05/2005
2	Biomarkers (Surrogate Marker)IBA 03/2006 - 05/2005
1	Glycerophospholipids (Phosphoglycerides)IBA 06/2023
1	Choline (Choline Chloride)IBA 06/2023
1	Acetyl Coenzyme A (Acetyl-CoA)IBA 12/2020
1	AcetyltransferasesIBA 12/2020
1	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 11/2020
1	fatty-acid amide hydrolase (fatty acid amide hydrolase)IBA 11/2020
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 10/2020
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2019
1	Long-Acting Thyroid Stimulator (LATS)IBA 11/2018
1	olipudase alfaIBA 01/2018
1	LigandsIBA 06/2017
1	arginyl-glycyl-aspartic acidIBA 06/2017

Therapy/Procedure

12	Therapeutics 12/2019 - 03/2006
8	Enzyme Replacement Therapy 01/2018 - 01/2004
7	Transplantation 01/2018 - 12/2003
2	Injections 10/2012 - 10/2007
1	Immunotherapy 01/2023